A mouse model of HDFN that recapitulates human disease. (A) Breeding wild-type (WT) female mice with Kel2 transgenic male mice leads to HDFN. (B) HDFN depends on B-cell production of antibodies. (C) Transfusion of Kel2 transgenic blood into wild-type females also leads to HDFN. Professional illustration by Marie Dauenheimer.