Activation of β-catenin in T cells leads to T-cell leukemia. (A) Kaplan-Meier plot showing the survival curve of R26-βcat vs control mice. (B) Phenotype of thymic and splenic T cells from control and leukemic R26-βcat mice. Bottom panels show the expression of CD44 and CD25 of Lin⁻ (CD4⁻CD8⁻CD3⁻) cells from control thymocytes and R26-βcat tumor cells. Data are representative of 6 mice per genotype. (C) Kaplan-Meier plot illustrating the survival curves of mice transplanted with different numbers of total R26-βcat tumor cells.