EBF1 role in lymphomagenesis. (A) Ectopic expression of EBF1 in 2 independent DLBCL cell lines induced IRF8 and BCL6 expression while decreasing PRMD1 levels. (B) DLBCL cells ectopically expressing EBF1 became significantly resistant to apoptosis induced by H₂O₂ and serum deprivation (*P < .01, Student t test); ctrl (control) and 10% indicate the basal apoptosis rate in cells exposed to vehicle or grown in media supplemented with 10% fetal bovine serum, respectively. Bars labeled 0% correspond to cells grown in serum-deprived conditions The H₂O₂ data were collected at 24 hours and the starvation data at 48 hours; these results were confirmed in 3 independent biological replicates, and the data displayed represent the mean and standard deviation of a biological replicate.