ASA is less effective in Fpr2/3-deficient mice. Wild-type (Fpr2/3^+/+) and null (Fpr2/3^−/−) mice were subjected to 30 minutes’ clamping of the superior mesenteric artery, followed by a 90-minute reperfusion phase. Mice received vehicle (1 mL/kg) or the reported doses of ASA intraperitoneally 30 minutes before ischemia. Bars report the number of neutrophils adherent (A) or emigrated (B) into the subendothelial tissue. Mean ± SEM of 8 mice per group. *P < .05, **P < .01, ***P < .001 vs the respective vehicle group.