Figure 3
Figure 3. LC/MS/MS-based lipidomic analysis. (A) Left panel. Spectrum of relative peaks for LXA4 and LXB4. Right panel, LXA4 signature fragment ions reported as m/z, highlighting the 2 diagnostic fragments at 115 and 351 (351 is the ion mass). (B) Measurements of LXA4 levels and other bioactive lipid mediators in mouse plasma. Besides LXA4, values for LXB4, leukotriene (LT) B4, 5-HETE, 12-HETE, and 15-HETE are reported as measured in wild-type (Fpr2/3+/+) and null (Fpr2/3−/−) mice, in sham or ischemic (30 minutes’ occlusion of the mesenteric artery) conditions. Mean ± SEM of 6 mice; *P < .05 vs respective sham-operated mice.

LC/MS/MS-based lipidomic analysis. (A) Left panel. Spectrum of relative peaks for LXA4 and LXB4. Right panel, LXA4 signature fragment ions reported as m/z, highlighting the 2 diagnostic fragments at 115 and 351 (351 is the ion mass). (B) Measurements of LXA4 levels and other bioactive lipid mediators in mouse plasma. Besides LXA4, values for LXB4, leukotriene (LT) B4, 5-HETE, 12-HETE, and 15-HETE are reported as measured in wild-type (Fpr2/3+/+) and null (Fpr2/3−/−) mice, in sham or ischemic (30 minutes’ occlusion of the mesenteric artery) conditions. Mean ± SEM of 6 mice; *P < .05 vs respective sham-operated mice.

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