Scale schematic of VWF missense variants associated with levels of VWF or FVIII levels in African Americans (AAs). The location of each of VWF variants with significant univariate associations with VWF and/or FVIII levels in AAs are indicated by arrows to the corresponding commonly annotated VWF domain (top). An alignment with the recently revised VWF domain annotation⁶  is also shown (bottom). Two variants, I1380V and N1435S, are in strong LD (r² = 0.89) and are therefore represented together.