ADDSs cover a new area of antithrombotic utility: TTT. Using ADDSs has the potential to provide ATA pro-drugs with an immediate onset (local activation) and a duration of action lasting hours to days, targeted carriers that capitalize on the dynamic nature of thrombi, and differences between preformed hemostatic and subsequently formed occlusive clots. This approach might extend the medical utility of fibrinolytic or anticoagulant ATAs.