VWF alleles with an independent effect on VWF and FVIII levels. Independent effect on levels was evaluated by Johnsen et al by performing a multivariable regression model adjusted for age, sex, genetic ancestry, and the remaining missense variants.1 Updated structure of VWF (Zhou YF, Eng ET, Zhu J, Lu C, Walz T, Springer TA. Sequence and structure relationships within VWF. Blood. 2012;120(2):449-458) showing ligand-binding regions for FVIII, GpIbα and collagen are indicated by blue bars. Amino acid residues shown in bold red text are associated with higher VWF or FVIII levels. Ex, exon.
