The mutational driver landscape of newly diagnosed multiple myeloma. (A) Driver gene frequencies in the total data set (N = 1273) identified by either frequency-based (yellow) or functional-based (blue) methods or both (red). (B) Cancer clonal fraction (CCF) of driver genes colored by oncogene (ONC; red) or tumor suppressor gene (TSG; blue) score. Genes in gray did not score for either ONC or TSG. Genes are ordered by mean CCF (thick line). (C) ONC (red) and TSG (blue) scores determined by the 20/20 rule (dark) or SomInaclust (light). (D) Mean CCFs of ONCs and TSGs.