Molecules capable of promoting proliferation and survival and antiapoptotic mechanisms in RS cells. According to the study of Cader et al, in EBV-driven lymphomagenesis, the DDR1 pathway is likely to be an alternative or additional pathway to CD40 or CD30 signaling in the pathogenesis of Hodgkin lymphoma. IκB, inhibitory NF-κB. Professional illustration by Debra T. Dartez.