Lineage involvement. (A) Sample processing. (B) Distribution of lineage involvement patterns for all mutations (n = 116), single DNMT3A mutations (n = 56), and single TET2 mutations (n = 24). (C) CD14⁺:CD19⁺ VAF ratio in DNMT3A (n = 23) and TET2 (n = 11) individuals with myelolympho-B mutation. (D) Mean VAF for myeloid, myelolympho-B, and multipotent DNMT3A and TET2 mutations. *P < .05. NGS, next-generation sequencing; WT, wild-type.