Algorithm for reclassifying SMM and active MM. *Consider including patients with the following FISH: deletion 17p, t(4;14), and 1q21 gains as active MM; this population could account for as many as 30% of SMM patients. ^§Consider using more than 1 fluorodeoxyglucose-avid lesion on PET/CT in lieu of MRI. iFLC, involved FLC; uFLC, uninvolved FLC; WbMRI, whole-body MRI.