Morphologic variants and immunophenotypic profiling in EBV-positive diffuse large B-cell lymphomas of the elderly. (A,E,I,M,Q,U) The monomorphic subtype is characterized by monotonous sheets of large transformed B cells. (B,F,J,N,R,V) Polymorphic DLBCL-like subtype shows canonical large B-cell neoplasm morphology, characterized by a high density of large neoplastic cells and scattered cells with Reed-Sternberg (RS)-like and Hodgkin-like features. (C,G,K,O,S,W) The polymorphic HL-like subtype shows a lower density of neoplastic cells with RS-like and Hodgkin-like features. (D,H,L,P,T,X) The polymorphic PLPD-like subtype is DLBCL with polymorphic LPD-like features. It is characterized by a low density of neoplastic cells without HL-like features. EBV-positive DLBCL of the elderly is predominantly the ABC subtype. (A,E,I,M,Q,U) Interestingly, the monomorphic case presented in this figure shows the GCB subtype. All polymorphic subtypes show the ABC-DLBCL molecular phenotype.