Figure 5
Evaluation of the mutation status of STAT3 and immunohistochemistry for pY-STAT3 in indolent T-LPD. (A) Sanger sequence chromatograms for STAT3 mutation hot spots showing only wild-type sequences. The amino acid residues corresponding to the sequence evaluated are shown over each chromatogram (F, forward primer sequencing; R, reverse primer sequencing). The domains of the STAT3 protein were shown based on the National Center for Biotechnology Information Reference Sequence NP_644805. The locations of the STAT3 hot spots were indicated based on the STAT3 SH2 domain mutations identified in T-cell and NK-LGLL cases in 2 recent studies.16,17 (B) Immunohistochemical stain for phospho-STAT3 showing only a few scattered positive cells as well as fewer strongly positive cells. (Immunohistochemical stain, original magnification ×200.)

Evaluation of the mutation status of STAT3 and immunohistochemistry for pY-STAT3 in indolent T-LPD. (A) Sanger sequence chromatograms for STAT3 mutation hot spots showing only wild-type sequences. The amino acid residues corresponding to the sequence evaluated are shown over each chromatogram (F, forward primer sequencing; R, reverse primer sequencing). The domains of the STAT3 protein were shown based on the National Center for Biotechnology Information Reference Sequence NP_644805. The locations of the STAT3 hot spots were indicated based on the STAT3 SH2 domain mutations identified in T-cell and NK-LGLL cases in 2 recent studies.16,17  (B) Immunohistochemical stain for phospho-STAT3 showing only a few scattered positive cells as well as fewer strongly positive cells. (Immunohistochemical stain, original magnification ×200.)

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