Indolent T-LPD of the ileum (case 10). (A) A resection specimen showing diffuse, band-like infiltration of the lamina propria, and, focally, the submucosa by lymphoid infiltrate. (B) Lymphoid infiltrate distorts and displaces intestinal crypts, but does not invade them. (C) The infiltrate is composed of small, mature-appearing lymphoid cells with scant pale cytoplasm. (D) The cells are positive for TIA-1. The majority of the cells are positive for (F) CD8, with fewer (E) CD4-positive cells admixed. (A: hematoxylin and eosin [H&E], original magnification ×10; B: H&E, original magnification ×100; C: H&E, original magnification ×400; D: immunohistochemical stain, original magnification ×400; E-F: immunohistochemical stain, original magnification ×100.)