Identification of cell-subset–specific HMRs and potential rHMRs. (A-B) Total number of cell-subset–specific identified HMRs are plotted. (A) Location of HMRs relative to CGIs. Shelves, shores, and open sea regions are defined as for Figure 1. (B) Distribution of HMRs relative to promoter regions, 5′ UTRs, intragenic and away from gene coding areas (ie, distant). (C) Total number and percentage of dHMRs correlating with differential gene transcript expression by cell type. (D-E) Proportion and distribution of cell-type–specific HMRs correlating with gene expression (ie, potential rHMRs) with regard to CGIs (D) and genomic location (E). UTR, untranslated region.