Figure 4
Human CD40L+ CD8+ T cells express helper cytokines but not cytolytic molecules. (A) CD8+ and CD4+CD45RA− memory T-cell subsets were sorted after 6-hour P/I stimulation and messenger RNA expression of cytokine genes was analyzed with microarrays. (B) CD8+ T cells were stimulated with P/I and were analyzed for CD40L expression and coexpression of cytokines using an intracellular cytokine assay. (C) CD8+ T cells were stimulated and analyzed for CD40L and degranulation (CD107a+) as well as for coexpression of perforin and granzyme B. (B-C) One representative experiment out of 5 is shown.

Human CD40L+ CD8+ T cells express helper cytokines but not cytolytic molecules. (A) CD8+ and CD4+CD45RA memory T-cell subsets were sorted after 6-hour P/I stimulation and messenger RNA expression of cytokine genes was analyzed with microarrays. (B) CD8+ T cells were stimulated with P/I and were analyzed for CD40L expression and coexpression of cytokines using an intracellular cytokine assay. (C) CD8+ T cells were stimulated and analyzed for CD40L and degranulation (CD107a+) as well as for coexpression of perforin and granzyme B. (B-C) One representative experiment out of 5 is shown.

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