Schematic overview of TF signaling complexes. The TF–FVIIa binary signaling complex signals via PAR2, whereas the ternary TF–FVIIa–FXa coagulation signaling complex activates both PAR2 and PAR1. TF pathway inhibitor inhibits the coagulation and signaling function of the ternary complex. Thrombin signals through PAR1 to induce inflammatory responses. Binding of aPC to EPCR switches the specificity of PAR1–thrombin signaling to mediate protective anti-inflammatory responses. Antibody 10H10 targets the TF–FVIIa binary signaling complex and disrupts the TF–integrin interaction.