Model of how transcription factor C/EBPα-induced microRNA miR-30c inactivates Notch1 during granulopoiesis and is downregulated in AML. (A) During granulopoiesis, C/EBPα transactivates miR-30c, which in turn leads to Notch1 and Trib2 repression, resulting in myeloid differentiation. (B) In AML, C/EBPα fails to transactivate miR-30c, which results in a lack of Notch1 inhibition.