Platelets transfer functional microRNA to alter endothelial cell metabolism. Activated platelets shed microparticles containing Ago2•miR-223 and the MPs are subsequently engulfed by endothelial cells. Ago2•miR-223 then targets endothelial cell mRNA molecules and subsequently inhibits translation and protein synthesis. Adapted from Figure 6 of Laffont et al that begins on page 253. Professional illustration by Debra T. Dartez.