Figure 3
Immunohistochemical analysis, EBER ISH, and molecular analysis in a case with γδ T-cell phenotype (case 6). (A) Skin biopsy showing a dense lymphoid infiltrate in the dermis surrounding blood vessels and adnexae (hematoxylin and eosin stain, original magnification ×100). (B) EBER ISH reveals that practically all lymphoid cells are EBER positive (original magnification ×100). (C-G) The cells are CD3 (C) and TIA-1 positive (D) but negative for CD8 (E) and β F1 (F). Note that the lymphoid cells are TCR-γ positive (G) (C-G: immunoperoxidase, original magnification ×400). (Inset F-G: immunoperoxidase, original magnification ×630). (H) Higher magnification of the EBER ISH (original magnification ×400). (I) TCR-δ gene rearrangement shows a dominant monoclonal peak of 220 base pairs.

Immunohistochemical analysis, EBER ISH, and molecular analysis in a case with γδ T-cell phenotype (case 6). (A) Skin biopsy showing a dense lymphoid infiltrate in the dermis surrounding blood vessels and adnexae (hematoxylin and eosin stain, original magnification ×100). (B) EBER ISH reveals that practically all lymphoid cells are EBER positive (original magnification ×100). (C-G) The cells are CD3 (C) and TIA-1 positive (D) but negative for CD8 (E) and β F1 (F). Note that the lymphoid cells are TCR-γ positive (G) (C-G: immunoperoxidase, original magnification ×400). (Inset F-G: immunoperoxidase, original magnification ×630). (H) Higher magnification of the EBER ISH (original magnification ×400). (I) TCR-δ gene rearrangement shows a dominant monoclonal peak of 220 base pairs.

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