Cumulative effects of the 6 BCP-ALL risk alleles (rs4132601, IKZF1; rs7089424, ARID5B; rs2239633, CEBPE; rs3731217, CDKN2A/CDKN2B; rs10828317, PIP4K2A, and rs3824662, GATA3). (A) Distribution of risk alleles in controls (black) and ALL cases (grey). (B) Plot of the increasing ORs for BCP-ALL with increasing number of risk alleles. The ORs are relative to the median number of 6 risk alleles; vertical bars correspond to 95% confidence intervals. The distribution of risk alleles follows a normal distribution in both cases and controls, with a shift toward a higher number of risk alleles in cases. Horizontal line denotes the null value (OR = 1.0).