Viral reactivation. (A) AdV reactivation and monitoring of the specific immune response in patient 1. Detection of AdV-specific T-cell responses by IFNγ ELISpot (striped bars) and CD19.CAR transgene by Q-PCR (black circles) are illustrated. The light gray diamond denotes the time of adenovirus antigen detection in stool. (B-C) EBV reactivation and immune responses in patients 7 and 8, respectively. Detection of EBV-DNA viral load by Q-PCR (light gray squares), CD19.CAR transgene by Q-PCR (black circles), and EBV-specific T-cell responses (striped bars) by IFNγ ELISpot in the PB are illustrated. Arrows denote time of CD19.CAR-VSTs infusions.