Figure 3
![Figure 3. PD-L1 expression on parenchymal cells is critical for suppression of acute GVHD. Lethally irradiated wt B6 or PD-L1−/− recipients were given BM cells from PD-L1−/− or wt B6 mice, respectively, to create chimeras. We also created control chimeras (wt→wt). After 3 months, these chimeras were reirradiated and infused with allogeneic BALB/c BM cells with 10 × 106 BALB/c splenocytes. Kaplan–Meier survival curve of transplanted mice (n = 8–11/group). wt→ wt vs PD-L1−/−→wt chimeras [P = .06]; wt→wt vs wt→PD-L1−/− chimeras [P < .0001]; PD-L1−/−→wt vs wt→ PD-L1−/− chimeras [P = .0009]). Data are representative of 2 independent experiments.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/122/17/10.1182_blood-2013-05-500801/4/3062f3.jpeg?Expires=1726840287&Signature=0xTRpDejl~B7EQ6BPcFHvRqwwdYTD7oVb4aCAA9BUwR1lF1auyXOr~VvmwS3YUIIiPvewmQ-U8Do8V14KU5rNyif6pNoj~LA1xvxFMXP4NNZWOrirvyuGhc8OcapfYQBi~vzEyBFb3H85RwEkJJck6f4ZZfR7J2s2JEYrnv1MNGnE-e~z8WcS5YQkqzgchAZza9wH7IW1JqIXPUMoX6mO09p5Er2sBm5bN27NsP9rEdoADCo0hn~qyhwH4YB6FxuDC~Z8j-WGaU9FS0fJWoVhy~NYnYO~tdWaucfgK81VTa8Um57KT4QOatugH--v~waXE9JnBR9SCzQO3sFFoIsxw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
PD-L1 expression on parenchymal cells is critical for suppression of acute GVHD. Lethally irradiated wt B6 or PD-L1−/− recipients were given BM cells from PD-L1−/− or wt B6 mice, respectively, to create chimeras. We also created control chimeras (wt→wt). After 3 months, these chimeras were reirradiated and infused with allogeneic BALB/c BM cells with 10 × 106 BALB/c splenocytes. Kaplan–Meier survival curve of transplanted mice (n = 8–11/group). wt→ wt vs PD-L1−/−→wt chimeras [P = .06]; wt→wt vs wt→PD-L1−/− chimeras [P < .0001]; PD-L1−/−→wt vs wt→ PD-L1−/− chimeras [P = .0009]). Data are representative of 2 independent experiments.
