Motif analysis of peak regions reveals clustering of consensus sites and anticipation of ETS, GATA, E-BOX, and RUNX TF binding. The number of peaks for combinations involving binding of 1, 2, 6, or all 7 factors are shown on the left of the figure (red = bound; blue = unbound). A complete set of all combinations involving binding of 1 or more factors is shown in supplemental Table 3. On the right are the fractions of regions with Ets, Gata, E-Box, and Runx motifs corresponding to the binding pattern on the left. Regions bound by 1 class of TF in human HSPCs have motifs for other members of the heptad, irrespective of whether these other factors are bound at that region or not.