Figure 4
![Figure 4. Commensal germs and MyD88 are dispensable in G-CSF–mediated feedback. (A) Flow cytometry of peripheral blood from neutropenic GF C57BL/6 mice and controls (n = 3). (B) Absolute marrow cell numbers in both hind limbs of GF C57BL/6 mice. Note the similarity of changes in GF mice compared with SPF-kept C57BL/6 (n = 3). p(LSK) = 0.04; p(GMP) = 0.05; p(CMP) = NS; p(MEP) = NS. (C) Plasma G-CSF levels in C57BL/6 and GF mice after neutrophil depletion with 1A8 versus controls. Note the significant increase of G-CSF in neutropenic mice and decreased baseline G-CSF levels in GF mice compared with animals maintained under SPF conditions [n(GF) = 3, n(C57BL/6) = 3; p(C57BL/6) = 0.04; p(GF C57BL/6) = 0.02].](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/121/5/10.1182_blood-2012-05-429589/4/zh89991301520004.jpeg?Expires=1724232285&Signature=ox9l9m3AfVb7VvB-2GMQNqWvsTyuCRSF8g03g6EImYwNuXH22FoHFwvGKfOnkP4ceMCIKCiq~QMzMvg8ERPuM5bF0riO6GuYBrqBsEAQ7R0jc3bgxgk3B9yDvojk~DLDr1FoRCjybEKMxXCVpker49fi0A97FGpk7w4r-SS-hi0JM09lIXQQLdtr06ryEbrCkPLP5VoEDquyDRF5QvW~-YqmfpwSTIseB2TQfIglMlriT~qv1HMic8xKAArrR2hkv3YsVuSVomLMtL6LBdBgHXB7fjpKyElEGusyqI0Fd92qtii3vjMZhuxKOKz1yhrdVe6iQHNh5a9XFz7v5RAYpA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Commensal germs and MyD88 are dispensable in G-CSF–mediated feedback. (A) Flow cytometry of peripheral blood from neutropenic GF C57BL/6 mice and controls (n = 3). (B) Absolute marrow cell numbers in both hind limbs of GF C57BL/6 mice. Note the similarity of changes in GF mice compared with SPF-kept C57BL/6 (n = 3). p(LSK) = 0.04; p(GMP) = 0.05; p(CMP) = NS; p(MEP) = NS. (C) Plasma G-CSF levels in C57BL/6 and GF mice after neutrophil depletion with 1A8 versus controls. Note the significant increase of G-CSF in neutropenic mice and decreased baseline G-CSF levels in GF mice compared with animals maintained under SPF conditions [n(GF) = 3, n(C57BL/6) = 3; p(C57BL/6) = 0.04; p(GF C57BL/6) = 0.02].
