Neutropenia-induced feedback in NSG mice. (A) NSG mice received 1A8, RB6-8C5, or PBS. Flow cytometric analyses of marrows are shown. Note the significant changes of LSK, GMP, and MEP. (B) Absolute cell numbers in both femora and tibiae of NSG mice (n = 5). RB6-8C5: p(LSK) = 0.04; p(GMP) = 0.05; p(CMP) < 0.001; p(MEP) = 0.02; 1A8: p(LSK) < 0.001; p(GMP) = NS; p(MEP) = NS; p(CMP) = NS. (C) Plasma G-CSF and M-CSF levels in control and antibody-treated NSG mice. Note significant change of G-CSF [n(control) = 4; n(RB6-8C5) = 3; n(1A8) = 3]. G-CSF: p(RB6-8C5) = 0.003; p(1A8) < 0.001; M-CSF: p(1A8 and RB6-8C5) = NS.