Dosing schedule. During treatment phase 1 (cycles 1-8), panobinostat (3×/week), bortezomib (2×/week), and dexamethasone (the day of and after bortezomib) were administered on a 2-weeks-on/1-week-off schedule. Treatment phase 2 (cycles 9+) consisted of 6-week cycles (two 2-weeks-on/1-week-off repeating cycles), with bortezomib and the corresponding dexamethasone reduced to once per week during their scheduled weeks. IV, intravenous.