Loss of FLVCR is dispensable for HSC recovery from oxidative stress. (A) Twelve weeks after competitive transplantation, mice were exposed to 200 cGy of radiation, and hematopoietic recovery was assessed by flow cytometry of peripheral blood granulocytes. (B) A second cohort of transplanted animals was treated with arsenic trioxide (8 mg/kg intraperitoneally) given 12 and 16 weeks after transplant. Hematopoietic recovery was determined by flow cytometry of peripheral blood granulocytes. Open circles represent competitive transplantation with FLVCR-deleted bone marrow and treatment with arsenic trioxide or sublethal radiation. Closed circles represent competitive transplantation with FLVCR-deleted bone marrow. Black squares represent competitive transplantation with wild-type Cre⁺ donor cells and treatment with arsenic trioxide. Open squares represent competitive transplantation with wild-type Cre⁺ donor cells.