Molecular model of hVKORC1. (A) A backbone ribbon model of hVKORC1. Colors differentiate secondary structure elements, including transmembrane α-helices (blue), random coil (cyan), turn (green), and 1/2-helical segment (magenta). Conserved cysteine residue side-chains shown as yellow stick representations. (B) The simulation snapshot of the membrane-embedded structure of hVKORC1.