Expression of TH-polarization and CHL-associated CCRs as summarized in supplemental Table 1. (A) Representative flow plots and (B) summary of expression of TH1 and TH2 demonstrating a greater proportion of CHL-TH cells expressing TH1-related CCRs than TH2-related CCRs. (C) Greater expression of TH1-related CCRs in CHL-TH than in RLN-TH. (D) Representative flow plots and (E) summary of expression of TH-related cytokines measured by intracellular cytokine assay demonstrates greater or equivalent expression levels of TH1-related cytokines TNFα, IFNγ, and IL-2, along with IL-21 in CHL-TH compared with RLN-TH, with no measurable TH2-related cytokine expression (F). RLN comprised 6 samples, of which 3 were classified PH and 3 FH. Results for PH are additionally presented as a separate category in these figures for reasons described in the supplemental Material.