Multilineage human HSC reconstitution in BRGS mice. (A) Representative FACS plots at 8 weeks after transplantation in the BM, spleen, and thymus. (B) Human hematopoietic reconstitution in the spleens of BRGS and NOD-RG recipients (●: BRGS female; ○: BRGS male; ▴: NOD-RG female; ▵: NOD-RG male). There were no significant differences in the percentages of human CD45⁺ cells and human CD19⁺ B cells between these mice. (C) Human hematopoietic reconstitution in the thymi of BRGS and NOD-RG recipients. There were no significant differences in the percentages of human CD45⁺ cells and human CD3⁺ T cells between these mice. Symbols are as in panel B.