Kaplan-Meier estimates of OS and treatment-free survival according to the integrated mutational and cytogenetic model in the training series. (A) OS. (B) Probability of progressive disease requiring treatment according to IWCLL-NCI guidelines as indicated by treatment-free interval. Cases harboring TP53 and/or BIRC3 disruption (TP53 DIS/BIRC3 DIS) independent of cooccurring genetic lesions are represented by the red line. Patients harboring NOTCH1 mutations (NOTCH1 M) and/or SF3B1 mutations (SF3B1 M) and/or del11q22-q23 in the absence of TP53 and BIRC3 disruption are represented by the yellow line. Patients harboring +12 in the absence of the TP53 disruption, BIRC3 disruption, NOTCH1 mutations, SF3B1 mutations, and del11q22-q23 and patients wild-type for all genetic lesions (normal) are represented by the green line. Cases harboring del13q14 as the sole genetic lesion are represented by the blue line. nr indicates not reached.