Comparison and characterization of differentially expressed genes in subgroups of DLBCL patients treated with R-CHOP. (A) DEGs in patients with MDM2⁺ and MDM2^– DLBCL with WT-p53. (B) DEGs in patients with MDM2⁺ and MDM2^– DLBCL with MUT-p53. (C) DEGs in patients with p53⁺ and p53^– DLBCL with WT-p53. (D) MDM2 amplification shown by FISH. In every single cell, the orange signals (MDM2), by at least two times, outnumber the green signals (centromere 12). (E-F) Impact of MDM2 SNP309 on OS and PFS in DLBCL patients.