Differential DNA methylation between Naive and rTreg. (A) Functional annotations of the 450k array probes (left panel), 2315 DMPs between Naive and rTreg cells (middle panel), and probes associated with 127 RDMs between Naive and rTreg (right panel). (B) Unsupervised hierarchical clustering of the β values of both the significant DMPs (left panel) and RDM probes (right panel) resulted in distinct groupings of the Naive and rTreg samples. Each horizontal row in the heat map represents a CpG probe and each vertical column is a sample. The color indicates the level of methylation at each CpG in each sample, as described by the color key.