American Society of Hematology

Figure 5

$Figure 5. Effect of treatment on MAP and survival after hemin infusion into HbAS mice. (A) MAP in heterozygous HbAS mice infused with hemin followed by saline (n = 12, solid squares), MP4CO (n = 6, gray circles), or MP4OX (n = 6, open triangles). Values are means ± SD. *P < .016 vs saline. (B) Survival plot of HbAS mice infused with hemin followed by an 8 mL/kg infusion of saline (solid squares), MP4CO (gray circles), or MP4OX (open triangles). Arrows indicate the point of hemin administration and the duration of infusion of saline, MP4CO, or MP4OX. Values are fraction alive at indicated time points. *P < .016 vs saline.$

Effect of treatment on MAP and survival after hemin infusion into HbAS mice. (A) MAP in heterozygous HbAS mice infused with hemin followed by saline (n = 12, solid squares), MP4CO (n = 6, gray circles), or MP4OX (n = 6, open triangles). Values are means ± SD. *P < .016 vs saline. (B) Survival plot of HbAS mice infused with hemin followed by an 8 mL/kg infusion of saline (solid squares), MP4CO (gray circles), or MP4OX (open triangles). Arrows indicate the point of hemin administration and the duration of infusion of saline, MP4CO, or MP4OX. Values are fraction alive at indicated time points. *P < .016 vs saline.

This Feature Is Available To Subscribers Only