Figure 3
Effect of treatment post-H/R. LRS, MP4CO, MP4OX, or Hb (8 mL/kg) was infused into NY1DD sickle mice with implanted DSFCs 30 minutes after H/R (1 hour hypoxia at 7% O2/93% N2 followed by 30 minutes in room air) during the reoxygenation phase. Microvascular stasis was measured after an additional 30 minutes in room air (1 hour reoxygenation total) as described in Figure 2. The effect of pre-H/R + post-H/R treatment is shown on the right (×2 IV) where MP4CO or MP4OX was infused 24 hours before H/R and 30 minutes after H/R. Values are means + SD. N = 4 mice per treatment. *P < .017 vs LRS; #P < .026 MP4CO vs MP4OX.
