CIR for the BCR-ABL1-like expression signature, IKZF1-deleted, and high CRLF2 mRNA expression in newly diagnosed children with BCR-ABL1–negative, MLL wild-type BCP-ALL. CIR with death as a competing event was calculated using the method of Fine and Gray²⁵  in a pooled analysis of all 4 study cohorts and plotted against the time from initial diagnosis. For each feature, CIR at the 5-year follow-up is given in parentheses. (A) CIR of 94 BCR-ABL1-like and 442 non–BCR-ABL1-like BCP-ALL cases. (B) CIR of 136 IKZF1-deleted (DEL) and 721 IKZF1 wild-type (WT) cases. (C) Comparison between 55 cases with high CRLF2 expression and 481 cases with low CRLF2 expression.