Human blood cells colonize murine hematopoietic and lymphoid tissues. (A) Examples of spleen and lymph nodes of NSG wild-type mouse and NSG carrying 8-week-old teratomas. (B) LSC of femur bone of NSG mice carrying 8-week-old teratoma. The image on the left is the result of merging several images to give the reader a spatial reference of the areas in the femoral cavity from which the high resolution images on the right were obtained. White arrows indicate human CD45⁺ positive cells (green), whereas mouse laminin is stained red. Femurs of wild-type NSG mice and a secondary IgG were used as negative controls.