Figure 4
![Figure 4. Lyl1 is required for Lmo2-driven leukemogenesis. (A) Normalization of gene expression in Lmo2;Lyl1−/− thymocytes. A heat map shows the expression levels of the top 40 Lmo2-upregulated genes in wild-type (wt), Lmo2-transgenic (Tg), and Lmo2;Lyl1−/− DN thymocytes. (B) A heat map shows the expression levels of the top 40 Lmo2-downregulated genes in DN thymocytes of mice of the indicated genotypes. Labels are as in (A). (C) Kaplan-Meier survival curve of mice of the indicated genotypes. P < .001 between Lmo2;Lyl1+/− and Lmo2;Lyl−/− (log-rank [Mantel-Cox] test).](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/122/12/10.1182_blood-2012-09-458570/4/2093f4.jpeg?Expires=1724247048&Signature=cFsWAQ15mQGHwOkZKq6NusM-Rwv167DzEZBwcvsgud8ihzj2U9lL15ic-o~FgnfSAzq9EruBiBV6g3dWM643K0lsDIrtsWId1Mi6RXcpnaBc55ch3vSajZJxWzQPezvxDgUvF9XBJryWEReMety5KCwzIUKbBFuJX70FMxr4ylv-MOsLnQSEEASz6VrlxZiSYNMH5iwwfiRafAFBYDnz7MZaw7Q~dUt2ZHcL4ro0VJVJaSi3BukznIBry--fts8MNLPyAO5F4onwIUL8VmTyP7wD69YcCdKPyZUJnHCz8s6tw26bLgpiZKz4BiXuG6IwyCPCXFfA8qJEVlhOCQV7Xw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Lyl1 is required for Lmo2-driven leukemogenesis. (A) Normalization of gene expression in Lmo2;Lyl1−/− thymocytes. A heat map shows the expression levels of the top 40 Lmo2-upregulated genes in wild-type (wt), Lmo2-transgenic (Tg), and Lmo2;Lyl1−/− DN thymocytes. (B) A heat map shows the expression levels of the top 40 Lmo2-downregulated genes in DN thymocytes of mice of the indicated genotypes. Labels are as in (A). (C) Kaplan-Meier survival curve of mice of the indicated genotypes. P < .001 between Lmo2;Lyl1+/− and Lmo2;Lyl−/− (log-rank [Mantel-Cox] test).
