Effects of diabetes on binding interactions between fibrin and plasminogen purified from healthy controls or subjects with T1DM. A total of 9 controls and 9 T1DM samples, before and after improving glycemia, were analyzed. Representative data analysis plot of surface plasmon resonance binding studies using plasminogen purified from controls (A) and from diabetic samples before (B) or after (C) improving glycemic control. (D) Summary of surface plasmon resonance study data. PLG, plasminogen.