Disruption of the Peyer’s patches is a self-limiting process. (A) Time course of α₄β₇ and CD69 expression on circulating B cells in the peripheral blood after a single injection of poly(I:C). Data give the mean value of n = 3 individual mice ± SEM. The dashed line represents the baseline level of α₄β₇ expression before treatment. (B) Representative histograms are gated on CD19⁺ blood-borne B cells and give α₄β₇ and CD69 expression 12 hours after poly(I:C) treatment (thin gray line, isotype control). (C) Mice were treated with poly(I:C) as in Figure 1. Time course of total cell numbers in Peyer’s patches after the last injection. Each data point represents 1 individual mouse, and the mean of n = 5 mice per group is depicted as a bar. All data are representative of at least 2 independent experiments.