Prognostic value of copy number defects in adult T-ALL. (A) Human chromosomal ideograms showing the areas of genetic gain and loss identified by aCGH in adult T-ALL. Red bars represent areas of gain. Light blue bars represent areas of heterozygous copy number loss, and dark blue bars indicate homozygous deletions. (B-D) Kaplan-Meier survival curves in adult T-ALL patients (B) with or without the absence of bi-allelic deletion of the TCRG locus (ABD); (C) with or without homozygous CDKN2A/CDKN2B deletion; and (D) with or without heterozygous TP53 (17q) deletion, treated in the ECOG2993 clinical trial.