Sequential PET. Patient no. 1 (left): Sequential PET showing high initial pathologic uptake of ¹⁸F-fluorodeoxyglucose in soft tissue and bones before vemurafenib treatment, and significantly less uptake after 1 month and major regression after 4 months of vemurafenib treatment. Patient no. 2 (right): Similar substantial reduction of ¹⁸F-fluorodeoxyglucose uptake in all tissues involved. Reconstruction algorithm: OSEM_3D (5 iterations, 16 subsets, 9 mm Gauss filter). Volume rendering: Maximum Intensity Projection (Osirix Software). Display: BW inverse logarithmic table and range (min value = 0, max = 2.7 for SUV).