Adjusted mean differences for physical and health domains obtained in patients, transplanted before or after the age of 15 years, and controls. (A) Physical health and (B) mental health. A score below line 0 means worse outcomes for transplanted patients. Note that connecting lines among SF-36 outcomes are plotted for descriptive purposes only. ^†Mean differences between transplanted patients and matched control subjects adjusted for age, gender, education, marital status, and comorbidity. A negative sign indicates worse outcomes for transplanted patients. ^‡Exceeds minimally important difference (ie, 8 points for SF-36 scales and 2 points for PCS and MCS scales). ^§Statistically significant (α = 0.05).