Organization of the splenic structure is disrupted by the LCMV infection in platelet-depleted mice. Four groups of mice were treated with PBS or 40 μg of anti-GPIIb antibody 12 hours before, and 2 and 4 days after LCMV Armstrong infection or PBS injection (group 1, nontreated and noninfected; group 2, treated and noninfected; group 3, nontreated and infected; and group 4, treated and infected). Spleens were collected from mice killed 8 days later and thin tissue sections were stained for light or immunofluorescence microscopy analysis. Figure shows representative photomicrographs of H&E (40×, top row); T, B, and DCs (Thy1.2, B220, CD11c; 50×, second row); platelets (β3 integrin; 50×, third row); or fibroblastic reticular cells and LCMV (ER-TR7 and anti-LCMV, 50×, bottom row; n = 5).