miR-142 is a candidate miRNA governing DC subset specification. (A) K-means clustering of the 50 highest expressed miRNAs in the 8 mononuclear phagocyte subsets tested. DC-specific miRNAs (cluster 3) that are located inside protein-coding transcriptional units are indicated by asterisks (*). (B) Genomic localization and transcriptional control of miR-142 (left) and miR-155 (right). ChIP-Seq data of mRNA obtained from murine BM-derived DCs under steady-state conditions and at various time points (30, 60, 120, and 240 minutes) after 100 ng/mL of lipopolysaccharide exposure (shown only for transcript reads and polymerase activity). The binding of transcription factors is shown under physiologic conditions. A full description of the RNA-Seq and ChIP-Seq data can be found in Garber et al.³³