MAIT cells and CD161⁻ Vα7.2⁺ T cells in rectal mucosa of uninfected and HIV-infected individuals. Identification, frequency, and distribution of CD4 and CD8 subsets of rectal MAIT cells in 9 HIV-1–uninfected and 11 HIV-infected individuals (A-C). Spearman correlation between peripheral blood and rectal MAIT cells with time since HIV diagnosis (D), and a simple linear regression analysis of the relationship between frequency of blood MAIT cells and rectal MAIT cells (both are log₁₀-transformed) in uninfected and infected individuals (E). The frequency of CD161⁻ Vα7.2⁺ T cells (F) and IL-18R⁺ Vα7.2⁺ MAIT cells that did not express CD161 (G) in blood and rectal mucosa of HIV-1 infected and uninfected individuals. (H) Spearman correlation between the proportion of IL-18R⁺ Vα7.2⁺ MAIT cells that did not express CD161 and time since HIV diagnosis. (I) Frequency of CD4 T cells in the rectal mucosa. Open circles represent peripheral blood and closed circles represent rectal mucosa. Box and whisker plots show median, IQR and the 10th to 90th percentile.