Disruption of PPR in osteocytes shows no hematologic abnormalities. (A) Relative expression of PPR mRNA in femur and tibia (n = 4) from control (Con) and OCY-PPR (KO) mice. (B-D) PB counts showing (B) number of leukocytes, (C) % neutrophils, (D) number of platelets, and (E) number of lymphocytes in OCY-PPRKO and littermate controls (n ≥ 16). (F-G) Immunophenotypic analysis of hematopoietic cells in BM and spleen showing B cells (B220⁺ IgM⁺), granulocytes (Gr1⁺ CD11b⁺), erythroid cells (Ter119⁺ CD45⁻), monocytes (F4/80⁻ CD11b⁺), macrophages (F4/80⁺ CD11b⁺), T cells (CD4⁺), and cytotoxic T cells (CD8a⁺) in (F) BM and (G) spleens of 12-week-old OCY-PPRKO and littermate controls (n ≥ 16). Error bars represent mean ± SEM. *P < .05 by t test.