Genetic absence of Coro1A significantly reduces the severity of H pylori–induced gastritis. (A-D) Coro1A^+/+ and Coro1A^−/− mice were infected with H pylori X47 or inoculated with BB medium. H pylori–inoculated Coro1A^+/+ mice (solid squares, n = 11) and Coro1A^−/− mice (solid triangles, n = 12), BB medium–inoculated Coro1^+/+ mice (solid circles, n = 10). (A) Colonization of H pylori (log CFUs per gram of gastric tissue). (B) Number of PMNs in the high power field. (C) Gastritis scores.²⁶  (D) Representative histological sections of gastric mucosa stained with hematoxylin and eosin. Scale bars, 400 µm (top) and 100 µm (bottom). **P < .001.